Meaning of そもそも in Japanese

Definition of そもそも

そもそも(somosomo) 【抑 ·抑抑 ·抑々】

(conj) in the first place; to begin with; from the start; originally; ab initio
そもそもなぜ鳥は移動するのだろうか。
In the first place, why do the birds migrate at all?

そもそも指名手配しめいてはいされただけでは「犯人はんにん」じゃないです。

In any case, just being wanted by the police isn't enough to make you "a criminal."

そもそも彼かれが来たくるとしたら、驚きおどろきだ。

If he comes at all, it will be surprising.

The fact that they are talking at all.

Is there an existing meaning if the person in charge does not take the responsibility to begin with?

Most accidents, after all, happen around the corner, not in the rainforest.

そもそも君きみが来たくるとは驚いた。

I'm surprised you came at all.

そもそも何故私のわたし物ものだけ液晶えきしょうに線せんが入っていたはいるのか。

In any case why was it only mine that had a line in the LCD?

そもそもなぜ鳥とりは移動いどうするのだろうか。

In the first place, why do the birds migrate at all?

You shouldn't have come here to begin with.

彼女かのじょに口答えくちごたえすること自体じたいそもそも間違いまちがいだろ。

You're out of order in talking back to her in the first place.