(adj-na, n-adv, n)very hard; with utmost effort; with all one's might; desperately; frantically; for dear life; all-out effort; sticking at living in and defending one place→Related words:
一生懸命
一所懸命になって彼はその木に登った。 With great effort he climbed up the tree.
"Your work has been causing a lot of complaints from customers; I'm ordering you to leave immediately." "Oh, up yours! I didn't want to work here in the first place."